Mount Sinai Study Links Prenatal Acetaminophen Use to Autism and ADHD Risks

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TL;DR · Study at a glance · What it means in pregnancy · Practical recommendations · FAQ · Source

TL;DR (Quick Answers)

  • What’s new? A 2025 Mount Sinai study finds prenatal acetaminophen (Tylenol®/paracetamol) use may increase autism and ADHD risks.
  • How strong is the evidence? Gold-standard Navigation Guide Systematic Review across 46 studies and 100,000+ participants.
  • Does it prove causation? No—association only; higher-quality studies showed stronger links.
  • What should pregnant women do? Use cautiously, time-limited, lowest effective dose, and under medical supervision.
  • Why it matters? Over half of pregnant women worldwide use acetaminophen; even small risks can have large public-health effects.

Mount Sinai’s 2025 Review: The Study at a Glance

Researchers at the Icahn School of Medicine at Mount Sinai reviewed 46 international studies involving 100,000+ mother–child pairs. Published in BMC Environmental Health (August 13, 2025), this is the first meta-analysis in this space to apply the rigorous Navigation Guide framework.

Key findings:

  • Prenatal acetaminophen exposure is associated with increased risks of autism and ADHD.
  • Higher-quality studies were more likely to detect significant associations.
  • Plausible mechanisms include oxidative stress, endocrine disruption, and epigenetic changes that may affect fetal brain development.

Why This Matters During Pregnancy

Acetaminophen (Tylenol®, paracetamol) is the most-used over-the-counter analgesic and antipyretic in pregnancy, taken by 50%+ of pregnant women worldwide for headache, fever, and general pain. Historically considered safer than NSAIDs late in pregnancy, the new analysis urges cautious, time-limited use under clinician guidance.

Expert Perspective

“Given the widespread use of this medication, even a small increase in risk could have major public health implications.”
Diddier Prada, MD, PhD (Mount Sinai)

The team emphasizes association, not causation. Untreated pain or fever can also pose risks to mother and baby—hence the need to balance benefits and potential risks with a healthcare professional.


Practical Recommendations

  • Don’t change medication without medical advice.
  • When needed, use the lowest effective dose for the shortest possible time.
  • Ask about non-drug options for common discomforts.
  • Expect potential guideline updates as more data emerges.

Medical disclaimer: The content on 101Autism.com is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.


Related Reading on 101Autism.com


FAQ

Is it safe to take Tylenol while pregnant?
Yes, but use caution. Use the lowest effective dose for the shortest time and consult your doctor.

Does acetaminophen cause autism or ADHD?
No proof of causation. Multiple studies—including the 2025 Mount Sinai review—show an association, stronger in higher-quality studies.

What about not treating pain or fever?
Untreated fever can harm fetal development. Balance risks with your healthcare provider.

I used Tylenol during pregnancy—should I worry?
Most exposed children do not develop autism or ADHD. If concerned, discuss with your pediatrician.


Source

Mount Sinai Newsroom (Aug 13, 2025): Press release. Study published in BMC Environmental Health, 2025.

DrorAr101

My name is Adi, and I am the proud parent of Saar, a lively 17-year-old who happens to have autism. I have created a blog, 101Autism.com, with the aim to share our family's journey and offer guidance to those who may be going through similar experiences.Saar, much like any other teenager, has a passion for football, cycling, and music. He is also a budding pianist and enjoys painting. However, his world is somewhat distinct. Loud sounds can be overwhelming, sudden changes can be unsettling, and understanding emotions can be challenging. Nevertheless, Saar is constantly learning and growing, and his unwavering resilience is truly remarkable.

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